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Last week showed just how wild one week in the NFL can be. Underdogs went 7-6 straight up, and that included upsets ranging from Jacksonville over Buffalo to Denver over Dallas. That was our worst week picking games as a result. 

How will Week 10 play out? There are three games between teams with winning records, and that’s where the small upsets could happen. 

New Orleans travels to face Tennessee, and the Titans have the best record in the AFC right now. Cleveland and New England meet in a battle of 5-4 teams that have surprised for different reasons. The Sunday Night Football matchup features the Chiefs and Raiders in a pivotal AFC West game. 

It should be a fun week. Each week, Sporting News picks the NFL games straight up. A look at our track record so far: 

  • Week 9: 6-7 (before Monday’s game) 
  • Total: 87-48 (before Monday’s game) 

With that in mind, below are our picks and predictions for Week 10:  

POWER RANKINGS:
Titans, Patriots, Cardinals step up; Cowboys, Bills, Raiders fade for Week 10

(Getty Images)

NFL picks, predictions Week 10

  • Baltimore Ravens (-7.5) at Miami Dolphins 

Thursday, 8:20 p.m., FOX/NFL Network 

The Ravens have been tough for bettors to figure out because of their 1-5 ATS mark as a favorite, but they still rank second in the NFL in yards per game (427.9). Miami will have trouble keeping up for four quarters. Baltimore rolls on in the AFC North. 

Pick: Ravens 31, Dolphins 19 

  • Atlanta Falcons at Dallas Cowboys (-9)

Sunday, 1 p.m., FOX

The Cowboys won’t be caught by surprise by the Falcons, who have won three of their last four behind great play from Matt Ryan. Dak Prescott will be sharper in his second game back from a calf injury, but the Falcons will make it interesting. Remember last year’s 40-39 shootout? 

Pick: Cowboys 34, Falcons 27 

  • New Orleans Saints at Tennessee Titans (-2.5)

Sunday, 1 p.m., CBS

The Saints are a maddening team to pick, but the trend is fairly obvious. They are 1-4 ATS as a favorite and 3-0 ATS as an underdog. New Orleans won all those games. The Titans burnt us last week, but this week it’s the Saints that pull the upset. 

Pick: Saints 27, Titans 24 

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  • Jacksonville Jaguars at Indianapolis Colts (-10.5) 

Sunday, 1 p.m., CBS

The Colts have a top-five rushing attack with Jonathan Taylor, and that has allowed Carson Wentz to find a rhythm. Jacksonville stops the run (103.4 ypg.) and is coming off a big upset, but the Jags have yet to win a true road game under Urban Meyer. 

Pick: Colts 26, Jaguars 16 

  • Cleveland Browns at New England Patriots (-1.5) 

Sunday, 1 p.m., CBS

We have missed on Cleveland picks the last two weeks, but a different team surfaced in the victory against the Bengals. The Pats are hot, but they have lost to Dallas and New Orleans, teams with top-10 rushing offenses. This is the kind of victory that shows Cleveland can get back in playoff contention. 

Pick: Browns 27, Patriots 24 

  • Buffalo Bills (-13.5) at New York Jets 

Sunday, 1 p.m., CBS

The Bills have hit a rough patch where they are 1-2 S/U in their last three games and have failed to cover the spread as a favorite each time. The good news? The Jets have had multiple injuries at quarterback. It’s the right time for a get-well game. 

Pick: Bills 34, Jets 21 

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  • Detroit Lions at Pittsburgh Steelers (-8.5)

Sunday, 1 p.m., FOX

The Lions are coming off a bye week, and the Steelers are on a short week. It still won’t matter. Detroit allows 2.9 sacks per game, and the Lions have lost by an average of 9.8 points on the road. That sounds about right for Pittsburgh. 

Pick: Steelers 29, Lions 20 

  • Tampa Bay Buccaneers (-9.5) at Washington Football Team 

Sunday, 1 p.m., FOX

Tampa Bay is coming off a bye week for this NFC wild-card rematch from last season. Opposing quarterbacks have a 107.6 rating against Washington this season, the second-highest mark in the league. Tom Brady can work with that. 

Pick: Buccaneers 34, Washington 18 

  • Carolina Panthers at Arizona Cardinals (-10)

Sunday, 4:05 p.m., FOX

Sam Darnold is injured, and the Panthers will turn to P.J. Walker if he cannot play. The Cardinals proved they can play with Colt McCoy, who pinch-hit for Kyler Murray last week. We like the Cardinals at home either way. 

Pick: Cardinals 32, Panthers 19 

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  • Minnesota Vikings at Los Angeles Chargers  (-2.5)

Sunday, 4:05 p.m., FOX

The Vikings have lost five one-score games this season, a maddening trend that continues on the road against the Chargers. Los Angeles is 2-2 in one-score games, but Justin Herbert leads the way at home in another heart-breaker for Minnesota. 

Pick: Chargers 28, Vikings 27 

  • Philadelphia Eagles at Denver Broncos (-3)

Sunday, 4:25 p.m., CBS

This game is tough to pick. The Eagles are 3-2 ATS on the road this season, where they have played better in spots. Denver is coming off one of the biggest upsets of the season against Dallas but is just 2-2 at home. 

Pick: Eagles 29, Broncos 24 

  • Seattle Seahawks at Green Bay Packers (-4)

Sunday, 4:25 p.m., CBS

We have no idea what the quarterback combination will be, and that makes it tough to pick. Will it be Russell Wilson vs. Aaron Rodgers or Geno Smith vs. Jordan Love or some other combination? The Seahawks had a bye week, but they have lost their last nine games at Lambeau Field. 

Pick: Packers 24, Seahawks 21 

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  • Kansas City Chiefs (-2.5) at Las Vegas Raiders 

Sunday, 8:20 p.m., NBC

The Chiefs are a slight road favorite against the rival Raiders, who are coming off a disappointing loss to the Giants. It’s been an up-and-down season for both teams. Patrick Mahomes II leads the Chiefs to their third straight victory in another close call. 

Pick: Chiefs 27, Raiders 24 

  • Los Angeles Rams (-4.5) at San Francisco 49ers 

Monday, 8:15 p.m, ESPN

The Rams were out of sorts on both sides in the loss to Tennessee, but Von Miller might make his debut on what should be an imposing defense. San Francisco has a -9 turnover ratio. That won’t play well here. 

Pick: Rams 32, 49ers 22



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